This course comprises two topics of approximately equal weight. Molecular Architecture - elementary considerations of symmetry and formal classifications of molecules based on their symmetry elements and operations; spatial relationships between atoms or groups of atoms. Structures such as the amazing C60 molecule, the intricate polymer DNA, selected inorganic and organic coupled-ring systems, helical molecules, molecular knots, and chemical curiosities such as spirane and cubane are also described. Macrocyclic coordination chemistry: synthetic and naturally occurring macrocyclic ligands; binding of metals and anions; cyclodextrins; host-guest chemistry; supramolecular self-assembly; industrial, biological, medical and other applications.